Senior Research Associate (SRA-RR)
Sangamo Therapeutics
Brisbane, CA, USA
Posted on Friday, May 26, 2023
Position: Senior Research Associate (SRA-RR)
Job Id: 2023-5310-002SRA-RR # of Openings: 1
Pay Range: $136,500 - $163,668 per year
| Location: | Brisbane, CA |
Title: Senior Research Associate
Manager: Associate Director, Analytical Development
Department: Analytical Development
Location: Brisbane, CA
Sangamo Therapeutics is a genomic medicine company building value with cutting-edge work across four distinct but complementary technology platforms – gene therapy, cell therapy, in vivo genome editing, and in vivo genome regulation. Using its deep scientific expertise and proprietary zinc finger genome engineering technology, Sangamo is working to create genomic cures for patients suffering from severe genetic diseases for which today’s medicines can only treat symptoms. At Sangamo, we are passionate about transforming lives by building a robust, sustainable, differentiated, innovative, and high value genomic medicine pipeline that addresses patients with life-limiting conditions. Sangamo takes pride in being the first to edit endogenous human genes, first to treat patients with gene edited T cells, and first to treat patients with in vivo genome editing. Our top priority is to meet the needs of patients with commitment and compassion. Along with our commitment to science and to our patients, we also endeavor to create an inclusive environment that promotes and values diversity. Sangamo is a company where individuals can flourish, grow and develop their expertise.
We are seeking top talent to join our mission. Let’s build a better future together.
SUMMARY:
Sangamo Therapeutics is seeking a full-time (Mon-Fri, 40 hours/week) Senior Research Associate to design and perform assay development, optimization, feasibility, and validation as needed for all analytical molecular assays on AAV gene therapy and cell therapy drug substances and/or drug products supporting genome identity, product characterization, product stability, and product quality release.
ESSENTIAL FUNCTIONS:
- Perform laboratory molecular techniques including NGS (next generation sequencing), nucleic acid purification such as DNA and RNA, mRNA manipulation, qPCR (quantitative polymerase chain reaction) and ddPCR (digital droplet PCR).
- Collaborate with bioinformatics department to design, develop and interpret sequencing analysis pipeline for various molecular assays including NGS assays on short-read and long-read DNA sequencing platforms.
- Evaluate new technologies and methodologies to support and advance analytical capabilities on the therapeutic products.
- Troubleshoot challenging technical and experimental issues such as preparing single strand genome AAV sequence libraries on a double strand genome-based library preparation approach.
- Handle and troubleshoot instrument issues such as on DNA sequencers and qPCR instruments.
- Author assay development reports, method standard operating procedures (SOPs), and method transfer protocols to implement new analytical monitoring approaches on therapeutic products.
- Work closely with therapeutic program analytical lead to support as a contributing assay development author in regulatory filings with world health authority’s including the FDA, EMA, and other agencies.
- Represent as subject matter expert on analytical molecular assays to support Chemistry, Manufacturing and Controls (CMC) team on new pharmaceutical products.
- Supervise 2 Research Associate Contractors.
EDUCATION, EXPERIENCE AND SKILLS REQUIREMENTS:
- Bachelor's degree or foreign equivalent in Molecular Biology, Biochemistry, or a related field, plus five (5) years of progressively responsible experience in the job offered, or as a Research Associate or a related position.
- Must have five (5) years of progressively responsible experience with all of the following: Working with different molecular biology techniques including NGS, genomic DNA purification, PCR, qPCR, ddPCR; Utilizing relevant hands-on laboratory experience with molecular-based assay development in an academic research laboratory or biotechnology company; Utilizing NGS data analysis pipelines and statistical analysis software; Utilizing Illumina sequencing platforms; Troubleshooting molecular techniques and evaluating data of moderate complexity; and Documenting procedures and results and keep accurate detailed records.
- In the alternative, Employer will accept a Master’s degree or foreign equivalent in an above-stated field of study plus two (2) years of experience in the job offered or as a Research Associate or a related position and two (2) years of experience with all of the above stated skills. Employer will accept pre- or post- Master’s degree experience.
- Any suitable combination of education, training, or experience is acceptable.
Sangamo is an equal opportunity employer
Sangamo is committed to fostering belonging for all employees and embraces diversity, equity, and inclusion in recruiting and hiring. All qualified applicants for employment are encouraged to apply and will be considered without regard to an individual’s race, color, sex, gender identity, gender expression, religion, age, national origin or ancestry, citizenship, physical or mental disability, medical condition, family care status, marital status, domestic partner status, sexual orientation, genetic information, military or veteran status, or any other basis protected by federal, state or local laws
Sangamo is committed to fostering belonging for all employees and embraces diversity, equity, and inclusion in recruiting and hiring. All qualified applicants for employment are encouraged to apply and will be considered without regard to an individual’s race, color, sex, gender identity, gender expression, religion, age, national origin or ancestry, citizenship, physical or mental disability, medical condition, family care status, marital status, domestic partner status, sexual orientation, genetic information, military or veteran status, or any other basis protected by federal, state or local laws
Commitment to Safety
Sangamo requires all U.S. workers to be fully vaccinated against COVID-19 as of their start date. This requirement is a condition of employment at Sangamo, and it applies regardless of location or classification of role. If you are unable to receive the vaccine, you will have an opportunity to request a reasonable accommodation consistent with applicable laws.
Pay Range
The anticipated salary range is for candidates who will work in our Brisbane or Point Richmond, CA offices. The final salary offered to a successful candidate will be dependent on several factors that may include, but are not limited to, the type and length of experience with the job, type and length of experience within the industry, education, etc. This salary range may not apply to remote positions that work in other states.
The anticipated salary range is for candidates who will work in our Brisbane or Point Richmond, CA offices. The final salary offered to a successful candidate will be dependent on several factors that may include, but are not limited to, the type and length of experience with the job, type and length of experience within the industry, education, etc. This salary range may not apply to remote positions that work in other states.
Pay Range: $136,500 - $163,668 per year
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